helloquence-51716.jpg

Rapid Release of Knowledge

Journal Publications

*Members of our laboratory are in bold.

26 published

0 in press

0 in review

2 in preparation

  1. Heymans SV, Martindale CF, Suler A, Pouliopoulos AN, Dickinson RJ, Choi JJ. Simultaneous Ultrasound Therapy and Monitoring of Microbubble-Seeded Acoustic Cavitation Using a Single-Element Transducer. IEEE UFFC. 2017 [pre-print]
  2. Zhang C, Yao ZC, Ding Q, Choi JJ, Ahmad Z, Chang MW, Li JS. Tri-Needle Coaxial Electrospray Engineering of Magnetic Polymer Yolk-Shell Particles Possessing Dual-Imaging Modality, Multiagent Compartments, and Trigger Release Potential. ACS Appl Mater Interfaces. 2017. [in press]
  3. Pouliopoulos AN, Li C, Tinguely M, Garbin V, Tang MX, Choi JJ. Rapid short-pulse sequences enhance the spatiotemporal uniformity of acoustically driven microbubble activity during flow conditions. J. Acoust. Soc. Am. 140;2469. 2016 Link
  4. Pouliopoulos AN, Choi JJ. Superharmonic microbubble Doppler effect in ultrasound therapy. Phys Med Biol. 61(16):6154-6171. 2016 Link
  5. Koruk H, El Ghamrawy A, Pouliopoulos AN, Choi JJ. Acoustic Particle Palpation for Measuring Tissue Elasticity. Appl Phys Lett. 107:223701. 2015. Link
  6. Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R, Choi JJ. Enhancement of Non-invasive Trans-membrane Drug Delivery Using Ultrasound and Microbubbles during Physiologically Relevant Flow. Ultrasound Med Biol. 41(9):2435-2448. 2015. Link
  7. Pouliopoulos A, Bonaccorsi S, Choi JJ. Exploiting flow to control the in vitro spatiotemporal distribution of microbubble-seeded acoustic cavitation activity in ultrasound therapy. Phys Med Biol. 59(22):6941-57. 2014. Link
  8. Choi JJ, Carlisle RC, Coviello C, Seymour L, Coussios CC. Non-invasive and real-time passive acoustic mapping of ultrasound-mediated drug delivery. Phys Med Biol. 59(17):4861-4877. 2014.
  9. Coviello C, Kozick R, Choi J, Gyöngy M, Jensen C, Smith PP, Coussios CC. Passive acoustic mapping utilizing optimal beamforming in ultrasound therapy monitoring. J Acoust Soc Am. 137(5):2573. 2015.
  10. Graham S, Carlisle R, Choi J, Stevenson M, Shah A, Myers R, Fisher K, Peregrino MB, Seymour L, Coussios CC. Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes. J Control Release. 178:101-7. 2014.
  11. Carlisle R, Choi J, Bazan-Peregrino M, Laga R, Subr V, Kostka L, Ulbrich K, Coussios CC, Seymour LW. Enhanced Tumor Uptake and Penetration of Virotherapy Using Polymer Stealthing and Focused Ultrasound. J Natl Cancer Inst. 105(22):1701-10. 2013.
  12. Bazan-Peregrino M, Rifai B, Carlisle RC, Choi J, Arvanitis CD, Seymour LW, Coussios CC. Cavitation-enhanced delivery of a replicating oncolytic adenovirus to tumors using focused ultrasound. J Control Release. 169(1-2):40-7. 2013
  13. Choi JJ, Coussios CC. Spatiotemporal evolution of cavitation dynamics exhibited by flowing microbubbles during ultrasound exposure. J Acoust Soc Am. 132(5):3538-49. 2012.
  14. Baseri B, Choi JJ, Deffieux T, Samiotaki G, Tung YS, Konofagou EE. Activation of downstream signaling molecules following localized delivery of brain-derived neurotrophic factors to murine brain using focused ultrasound and microbubbles. Phys Med Biol. 57(7):N65-81. 2012.
  15. Konofagou EE, Tung YS, Choi JJ, Deffieux T, Baseri B, Vlachos F. Ultrasound-induced blood-brain barrier opening. Curr Pharm Biotechnol. 13(7):1332-45. 2012.
  16. Choi JJ, Selert K, Vlachos F, Wong A, Konofagou EE. Noninvasive and localized neuronal delivery using short ultrasonic pulses and microbubbles. Proc Natl Acad Sci U S A. 108(40):16539-44. 2011.
  17. Choi JJ, Selert K, Gao Z, Samiotaki G, Baseri B, Konofagou EE. Noninvasive and localized blood-brain barrier disruption using focused ultrasound can be achieved at short pulse lengths and low pulse repetition frequencies. J Cereb Blood Flow Metab. 31(2):725-37. 2011.
  18. Choi JJ, Wang S, Tung YS, Morrison B 3rd, Konofagou EE. Molecules of various pharmacologically-relevant sizes can cross the ultrasound-induced blood-brain barrier opening in vivo. Ultrasound Med Biol. 36(1):58-67. 2010.
  19. Choi JJ, Feshitan JA, Baseri B, Wang S, Tung YS, Borden MA, Konofagou EE. Microbubble size-dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo. IEEE Trans Biomed Eng. 57(1):145-54. 2010.
  20. Tung YS, Vlachos F, Choi JJ, Deffieux T, Selert K, Konofagou EE. In vivo transcranial cavitation threshold detection during ultrasound-induced blood-brain barrier opening in mice. Phys Med Biol. 55(20):6141-55. 2010.
  21. Baseri B, Choi JJ, Tung YS, Konofagou EE. Multi-modality safety assessment of blood-brain barrier opening using focused ultrasound and definity microbubbles: a short-term study. Ultrasound Med Biol. 36(9):1445-59. 2010.
  22. Tung YS, Choi JJ, Baseri B, Konofagou EE. Identifying the inertial cavitation threshold and skull effects in a vessel phantom using focused ultrasound and microbubbles. Ultrasound Med Biol. 36(5):840-52. 2010.
  23. Choi JJ, Wang S, Brown TR, Small SA, Duff KE, Konofagou EE. Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasound. Ultrason Imaging. 30(3):189-200. 2008.
  24. Choi JJ, Pernot M, Brown TR, Small SA, Konofagou EE. Spatio-temporal analysis of molecular delivery through the blood-brain barrier using focused ultrasound. Phys Med Biol. 52(18):5509-30. 2007
  25. Choi JJ, Pernot M, Small SA, Konofagou EE. Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice. Ultrasound Med Biol. 33(1):95-104. 2007. [92 citations. Top 5 cited articles in Ultrasound Med Biol in last 5 years]
  26. Seo J, Choi JJ, Fowlkes JB, O'Donnell M, Cain CA. Aberration correction by nonlinear beam mixing: generation of a pseudo point sound source. IEEE Trans Ultrason Ferroelectr Freq Control. 52(11):1970-80. 2005.

Conference Proceedings

  1. Konofagou EE, Choi JJ, Baseri B, Selert K, Tung YS. Mechanism and safety at the threshold of the blood-brain barrier opening in vivo. AIP Conf. Proc. 2010;1215:172-175.
  2. Tung YS, Choi JJ, Konofagou EE. Identifying the cavitation pressure threshold and skull Effects in a vessel phantom using focused ultrasound and microbubbles. AIP Conf. Proc. 2010;1215:186-189.
  3. Choi JJ, Feshitan JA, Wang S, Tung YS, Baseri B, Borden MA, Konofagou EE. The dependence of the ultrasound-induced blood-brain barrier opening characteristics on microbubble size in vivo. AIP Conf. Proc. 2009;1113:58-62.
  4. Wang S, Baseri B, Choi JJ, Tung YS, Morrison B 3rd, Konofagou EE. Qualitative and quantitative analysis of molecular delivery through the ultrasound-induced blood-brain barrier opening in mice. AIP Conf. Proc. 2009;1113:408-412.
  5. Konofagou EE, Choi JJ, Baseri B, Lee A. Characterization and optimization of trans-blood- brain barrier diffusion in vivo. AIP Conf. Proc. 2009;1113:418-422.
  6. Choi JJ, Pernot M, Small SA, and Konofagou EE. Noninvasive blood-brain barrier opening in live mice. AIP Conf. Proc. 2006;829:271-275. 

Invited Talks

  1. Choi JJ. Noninvasive MicroSurgery by Acoustic Cavitation, Institut Langevin. Paris, France. 12 May 2015
  2. Choi JJ. Noninvasive Surgery & Biopsy by Focused Ultrasound. iMed Conference, Lisbon, Portugal. 10-11 October 2014
  3. Choi JJ. Noninvasive Ultrasonic Cellular Surgery to Enhance Drug Uptake and Distribution. Departmental Seminar at University College London, London, UK. 12 March 2014.
  4. Choi JJ. Noninvasive and Real-Time Passive Acoustic Mapping of In Vivo Ultrasound-Mediated Drug Delivery. Pre-Clinical Ultrasound Imaging Symposium, Edinburgh, UK. 15 November 2013.
  5. Choi JJ. Noninvasive Ultrasonic Microsurgical Techniques to Enhance Drug Delivery Across Capillaries. School of Life Sciences Seminar Series, University Westminster, London, UK. 22 November 2013.
  6. Choi JJ. Exploiting Flow in the Design of Ultrasonic Pulse Shapes & Sequences for Cavitation-Mediated Drug Delivery. 19th European Symposium on Ultrasound Contrast Imaging, Rotterdam. The Netherlands. 23-24 January 2014.

Conference Presentations

  1. Choi JJ, Carlisle RC, Seymour L, Coussios CC. In vivo spatial correlation of cavitation activity to drug release in murine tumors. IEEE International Ultrasonics Symposium, Dresden, GER. Oct. 7-10, 2012.
  2. Choi JJ, Carlisle RC, Seymour L, Coussios CC. Passive acoustic mapping during cavitation-enhanced virotherapy in vivo. 12th International Symposium on Therapeutic Ultrasound, Heidelberg, GER. June 10-13, 2012.
  3. Choi JJ, Coussios CC. Spatio-temporal mapping and characterization of acoustic cavitation seeded by microbubbles and solid microparticles during focused ultrasound exposure. Acoustical Society of America Meeting, San Diego, CA, USA. Oct. 2011.
  4. Choi JJ, Carlisle RC, Coussios CC. Enhanced viral activity in tumors using focused ultrasound and microbubbles – a long term study. Acoustical Society of America Meeting, San Diego, CA, USA. Oct. 2011.
  5. Choi JJ, Coussios CC. Spatio-temporal mapping and characterization of acoustic cavitation seeded by flowing ultrasound contrast agents during pulsed focused ultrasound exposure. 11th International Symposium on Therapeutic Ultrasound, New York, NY, USA, Apr. 11-13, 2011.
  6. Choi JJ, Wang S, Tung Y-S, Baseri B, Morrison B 3rd, Konofagou EE. Delivery of pharmacologically-relevant sized molecules through the ultrasound-induced blood-brain barrier opening in vivo. Neuroscience, Chicago, IL, USA, Oct. 17-21. 2009.
  7. Konofagou EE, Choi JJ, Baseri B, Tung Y-S. Mechanism and safety of FUS-induced BBB opening, 9th International Society on Therapeutic Ultrasound, Aix-en-Provence, France, Sept. 21-24, 2009.
  8. Choi JJ, Feshitan JA, Baseri B, Wang S, Tung Y-S, Borden MA, Konofagou EE. Brain region and microbubble-size dependence of the focused ultrasound-induced blood-brain barrier opening in vivo. IEEE International Ultrasonics Symposium, Rome, ITA. Sept. 20-23, 2009.
  9. Choi JJ, Wang S, Lee A, Brown TR, Small SA, Duff KEK, Konofagou EE. Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer’s APP/PS1 mice using focused ultrasound. Neuroscience, Washington, DC, USA, Nov. 15-19. 2008.
  10. Choi JJ, Feshitan JA, Wang S, Tung Y-S, Baseri B, Borden MA, Konofagou EE. The dependence of the ultrasound-induced blood-brain barrier opening characteristics on microbubble size in vivo. 8th International Symposium on Therapeutic Ultrasound, Minneapolis, MN, USA, Sept. 10-13, 2008
  11. Choi JJ, Wang S, Tung Y-S, Morrison B, Konofagou EE. Trans-blood-brain barrier delivery of compounds at pharmacologically relevant molecular weights in the hippocampus of mice using Focused Ultrasound. Acoustics ’08, Paris, FRA. June 29 – July 4, 2008.
  12. Choi JJ, Wang S, Morrison B, Konofagou EE. Molecular delivery and microbubble dependence study of the FUS-induced blood-brain barrier opening in vivo. IEEE International Ultrasonics Symposium, New York, NY, USA. Oct. 28-31, 2007.
  13. Choi JJ, Small SA, Brown TR, Konofagou EE. Non-invasive generation and monitoring of ultrasound-induced blood-brain barrier opening in the murine hippocampus. International Society of Magnetic Resonance in Medicine, Berlin, DEU. May 20-25, 2007.
  14. Choi JJ, Small SA, Konofagou EE. Optimization of blood-brain barrier opening using focused ultrasound. IEEE International Ultrasonics Symposium, Vancouver, CAN. Oct. 3-6, 2006.
  15. Choi JJ, Pernot M, Small SA, Konofagou EE. Focused ultrasound-induced opening of the blood-brain barrier in mice. Acoustical Society of America Meeting, Providence, RI, USA. June 5-9, 2006.
  16. Choi JJ, Pernot M, Small SA, Konofagou EE. Noninvasive blood-brain barrier opening in mice. 5th International Symposium on Therapeutic Ultrasound, Boston, MA, USA. Oct. 27-29, 2006. 

Book Chapter

  • Konofagou EE, Choi JJ. “Ultrasound-induced treatment of neurodegenerative diseases across the blood-brain barrier.” Biomedical Applications of Vibration and Acoustics for Therapy, Bio-Effects and Modelling. Ed. Al-Jumaily A, Alizad A. New York: ASME, 2008. 63-80. 

Popular Press

  1. Nature Reviews Neurology. Research highlighted in “Pharmacology: New Methods to Permeabilize the Blood–Brain Barrier.” (Nov. 2011)
  2. Discover. Research results featured in “The Brain. Maybe You Do Need a Hole in Your Head—to Let the Medicine In.” (Nov. 2011)
  3. ScienceDaily.com. Research featured in "Engineers Use Short Ultrasound Pulses to Reach Neurons Through Blood-Brain Barrier" (Sept. 2011)
  4. Scientific American. Research featured in “Microbubbles Used to Breach the Blood-Brain Barrier–Bubbles may help lifesaving drugs cross a crucial boundary.” (Dec. 2010)
  5. MedicalPhysicsWeb. Research featured in “Ultrasound Pierces the BBB.” (July 2006)
  6. MIT Technology Review. Research featured in “A New Method for Getting Drugs into the Brain.” (June 2006)
  7. Acoustical Society of America Press Luncheon. “Knocking On Brain's Door: Breaking through the barrier using sound” (May 2006)

Patents

  1. Choi JJ, Koruk H. Method and device for acoustic particle palpation. 2015 [patent filed]
  2. Konofagou EE, Choi JJ, Borden MA. System and methods for opening a tissue. US patent application US 2011/0295105 A1.
  3. Konofagou EE, Choi JJ, Pernot M, Small SA. Systems and methods for opening of the blood- brain barrier of a subject using ultrasound. US 2009/0005711 A1.